Chronic gastrointestinal inflammation

Chronic gastrointestinal inflammation.

Chronic gastrointestinal inflammation is one of the most common types of inflammatory process which affects humans. It is diverse in aetiology, pathogenesis and manifestation. There are also features of chronic inflammation at different sites within the gastrointestinal tract which provide a common thread in terms of the approaches which may be used in investigating these intriguing processes. ...

Macrophage activation, chronic inflammation and gastrointestinal disease.

The involvement of macrophages in chronic inflammatory conditions has been the subject of considerable experimental investigation in recent years. Macrophages are able to secrete a wide range of biologically active compounds. They are important in the control of infection and, through their immunological and non-immunological receptors, macrophages interact with other cell types and a wide vari...

Chronic Low-grade Inflammation after Exercise: Controversies

Purinergic receptors in gastrointestinal inflammation.

Purinergic receptors comprise a family of transmembrane receptors that are activated by extracellular nucleosides and nucleotides. The two major classes of purinergic receptors, P1 and P2, are expressed widely in the gastrointestinal tract as well as immune cells. The purinergic receptors serve a variety of functions from acting as neurotransmitters, to autocoid and paracrine signaling, to cell...

Antimicrobial Peptides in Gastrointestinal Inflammation

Acute and chronic inflammations of mucosal surfaces are complex events in which the effector mechanisms of innate and adaptive immune systems interact with pathogenic and commensal bacteria. The role of constitutive and inducible antimicrobial peptides in intestinal inflammation has been investigated thoroughly over the recent years, and their involvement in various disease states is expanded e...